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Pioglaz

Pioglaz is a diabetes drug prescribed alongside diet and exercise to control blood sugar levels in people with Type 2 diabetes. A thiazolidinedione, or glitazone, Pioglaz may be used alone or with other diabetes drugs.

Other names for this medication:
Adride, Bioglita, Diaglit, Diamet, Diavista, Diazero, Dimbest, Euglim, Euroglip, Glimiprex, Glimitab, Glimsite, Glito, Gluconorm, Glucut, Glufit, Glyciphage, Glycirest, Ioglime, Matce, Mefomin, Metanorm, Metride, Mopady, Pioglar, Pioglu, Piomed, Pionorm, Pioplus, Piozone, Pizorad, Tgmet, Tribet, Triblend, Triexer, Triglycomet, Trigulin, Triopil, Vedapride

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Also known as: Pioglitazone

Description

Pioglaz is a medication that’s used to treat type 2 diabetes. This is a condition in which where your body has a high level of glucose (sugar) in your blood. Your pancreas normally makes a hormone called insulin, which takes glucose out of your blood and helps you use the sugar as a source of energy. With type 2 diabetes, your pancreas may not be making enough insulin to remove the sugar from your blood.

And if you have type 2 diabetes, your cells may also become insulin resistant. This means that your body makes insulin but isn’t responding to it by removing the sugar from your blood. So people with type 2 diabetes have high blood sugar levels.

What Pioglaz does

Pioglaz works by making your cells more sensitive to insulin. The goal is for your cells to take the glucose in your blood and use it more effectively as an energy source. Because you’re using your glucose more effectively, your blood glucose levels will decrease.

This lowers your risk of serious complications of type 2 diabetes, including heart disease, nerve damage such as neuropathy, and kidney failure.

How long does it take to work?

After you start using Pioglaz, it may take 7 days or longer before you notice any changes in your blood glucose level. It’s important to keep taking Pioglaz every day so that it can have the best chance to work in your body.

Dosage

Usual Adult Dose for Diabetes Type 2:

-Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day -Patients with congestive heart failure (New York Heart Association [NYHA] Class I or II): Initial dose: 15 mg orally once a day Maintenance dose: 15 mg to 45 mg orally once a day based on glycemic response as determined by HbA1c Maximum dose: 45 mg orally once a day Comments: -This drug exerts its antihyperglycemic effect only in the presence of endogenous insulin and therefore is not expected to be effective in patients with type 1 diabetes mellitus or diabetic ketoacidosis. -Patients concomitantly receiving an insulin secretagogue or insulin may need to reduce the dose of the insulin secretagogue or insulin if hypoglycemia occurs. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings

Detailed Pioglaz dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Pioglaz are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Pioglaz if you are allergic to pioglitazone, or if you have:

severe or uncontrolled heart failure; or diabetic ketoacidosis (call your doctor for treatment).

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

To make sure Pioglaz is safe for you, tell your doctor if you have ever had:

congestive heart failure or heart disease; a heart attack or stroke; eye problems caused by diabetes; bladder cancer; or liver disease.

Pioglaz may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Pioglaz if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Pioglaz. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Pioglaz is not approved for use by anyone younger than 18 years old.

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RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Standardization of medical terminology is essential in data transmission between health care institutes and in maximizing the benefits of information technology. The managers were asked to complete a short questionnaire and participate in an interview about the services offered, including needle turnover rates, number of clients, and use of peer educators. Among these, Actin was the most stable internal control in root, and GAPDH was the most stable housekeeping gene in cotyledon. Improving the evidence-base for access to primary health care in Canterbury: a panel study. There is increasing evidence that severe GAD autoimmunity may be associated with refractory epilepsy. To compare Schirmer tear test I (STTI) values collected in normal horses with and without an auriculopalpebral nerve block. This trial was registered at www.clinicaltrials.gov as study NCT0094398. In chronic cytotoxicity tests, the cytotoxic effect of these conjugates on human gastric cancer cells KATOIII was quite similar to that of free drugs or ricin, but greater than that of irrelevant conjugates, while they had a little effect on non-target cells, suggesting that the selective cytotoxicity on target cells of the conjugates be mediated by antibodies.

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We present here a patient with both cataplexy and RSBD following pontine encephalomalacia. Such parallel experimental studies will enable to validate PSA as a biomarker for tumor volume response and may link clinical PSA kinetics to actual tumor response. Expression of cancer testis antigens CT10 (MAGE-C2) and GAGE in gastrointestinal stromal tumors. In general, our results are in good agreement with experimental studies, and provide atomic-scale insights into the processes. FoxM1 binds to Cdh1, and FoxM1 degradation involves both D- and KEN-boxes present in the N-terminal part of FoxM1. Analysis of the correlation of 18 physical measurements in 3-month-old children. This is a rare case of a primary gastric lymphoma with another primary (sarcomatous) malignancy occurring synchronously in same patient. Although successful in demonstrating the use of Monte Carlo (MC) simulations of radiance in tissue optical characterization, the MC proved time consuming and impractical for clinical applications. Some DCIS is different molecularly from DCIS with co-existing IDC.

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Stress in the hospital is an every-day-reality, how can each of us cope with it?. Significant Association between Toll-Like Receptor Gene Polymorphisms and Posttransplantation Diabetes Mellitus. Self-reported discomfort scores were obtained throughout the day. Small overlap in resource use with unrelated native species, improved competitiveness, and production of novel allelochemicals are all believed to contribute to the invasiveness of introduced species. All patients were treated with bilateral symmetric inferior oblique myectomy. The diagnosis of HE requires the use of tests to evaluate cognitive functions. The interaction of cations with activity of soluble protein kinase C from mouse brain. We have previously used a magnetic resonance imaging (MRI) method to study gastric emptying of liquids. Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.

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