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Alpram (Alprazolam)
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Alpram

Alpram is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpram, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpram is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcalm, Aleez, Alparazole, Alpracon, Alprocontin, Alzom, Ambutech, Anzilum, Destres, Endolam, Fluti, Maxorest, Pacyl, Paxor, Prazil, Procalm, Propnix, Prozolam, Resolin, Restyl, Serex, Serxanti, Setlan, Tenan, Tenschem, Tensyl, Tensyn, Trustin, Xylonite, Zamitol, Zedel, Zeecam, Zolark, Zopral, Zorest

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Also known as: Alprazolam

Description

Alpram is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alpram is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alpram if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alpram or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alpram. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

Dosage

Take this medication by mouth as directed by your doctor. Dosage is based on your medical condition, age, and response to treatment. Your dose may be gradually increased until the drug starts working well. Follow your doctor's instructions closely to reduce the risk of side effects.This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Report any withdrawal reactions immediately.Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.Tell your doctor if your condition persists or worsens.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alpram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: kava, sodium oxybate.Other medications can affect the removal of Alpram from your body, which may affect how Alpram works. Examples include azole antifungals (such as itraconazole, ketoconazole), cimetidine, certain anti-depressants (such as fluoxetine, fluvoxamine, nefazodone), drugs to treat HIV (delavirdine, protease inhibitors such as indinavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (such as diphenhydramine), medicine for sleep or anxiety (such as diazepam, zolpidem), muscle relaxants, narcotic pain relievers (such as codeine), psychiatric medicines (such as chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients which cause drowsiness. Ask your pharmacist about the safe use of those products.Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

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Autotransplantation of kidney with contralateral nephrectomy in dogs. Localization of acid phosphatase activity in a giant cell tumor of bone. The isthmic organizer possesses midbrain- and cerebellum-inducing properties, and its positioning at the midbrain-hindbrain boundary is a crucial event that controls midbrain and cerebellum development. japonica populations on a large geographic scale, which is an important contribution to breeding and conservation of this marine crop. Other urinary marker tests discussed in this review include telomerase, cytokeratins, and vascular endothelial growth factor. Mucous membrane pemphigoid (MMP) is a heterogeneous group of autoimmune blistering disorders characterized by subepithelial separation and the deposition of immunoglobulins and complement along the basement membrane zone (BMZ). Five patients with macular edema caused by CRVO were examined using optical coherence tomography (OCT) through their clinical courses. Regardless of the underlying defect, the mainstay of therapy has been and remains immunoglobulin (Ig) replacement therapy, currently by intravenous infusion or subcutaneous injection.

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A new marker-transfer technique was used to produce recombinant CMV strains, to determine the drug susceptibility phenotypes conferred by 10 pol mutations (9 observed in clinical isolates). When the concentration of H2O2 is 0.01-1.0 mmol/L, Tiron can almost inhibit the loss of hair cells completely. The concentration of endotoxin in the dust samples was measured by the limulus amebocyte lysate (LAL) assay. In the gp41delta C20 mutant the helicase subunits have been genetically truncated to remove the 20 residue C-terminal tail peptide domains present in the wild-type enzyme. U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery. Despite minimal disparity at the sequence level, mammalian H3 variants bind to distinct sets of polypeptides.

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Localized enhancement of electric field in tip-enhanced Raman spectroscopy using radially and linearly polarized light. Use of drug interaction information in patient medication records. RECENT DEVELOPMENTS IN THE UNDERSTANDING OF AMINO-ACID AND PROTEIN METABOLISM BY SCHISTOSOMA MANSONI IN VITRO. The enzymes assayed included those associated with both labile and recalcitrant SOM degradation. Through shared medical appointments (SMAs) and a multidisciplinary team approach, Club Red provides lifestyle training in addition to evidence-based practice to reduce CVD risk factors in women. DMXB improved the auditory gating deficit seen in isolation-reared rats. EPR spin-trapping evidence for the direct, one-electron reduction of tert-butylhydroperoxide to the tert-butoxyl radical by copper(II): paradigm for a previously overlooked reaction in the initiation of lipid peroxidation.

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A telephone survey of 200 Scottish workplaces, based on a stratified random sample of workplaces with 50 or more employees, was conducted in 1996. We illustrate the problems related to physiologic signal analysis with representative examples of human heartbeat dynamics under healthy and pathologic conditions. Extraction of ragweed pollen with water organic soluble solvents. Small mammal community succession on the beach of Dongting Lake, China after the Three Gorges Project. DRE, PSA-serum level measurements, transrectal ultrasound and prostate biopsy are essential in the early diagnosis of PCA. In seven countries (Austria, Denmark, Germany, The Netherlands, Portugal, Slovenia and Switzerland) 146 GPs and 284 patients aged 70 and over were interviewed about the use and the acceptability of these two methods. Thus, NGF was able to promote complete repair in human skin and corneal ulcers which were poorly or non-responsive to conventional topical and systemic treatments. Gpr177 (Evi/Wls) is a Wnt-specific cargo receptor that is required for the secretion of Wnt ligands. Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal.

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In this review, I provide cross-referencing of well-characterized constituent transporters according to (i) transport mode, (ii) energy coupling mechanism, (iii) phylogenetic grouping, and (iv) substrates transported. A plot of the scattering angle against impact parameter showing distinct signs of chaos is presented. To evaluate clinical attitudes and preferences of large community sample of both specialized physicians and general practitioners, included in an educational program, endorsed by SIIA and aimed at improving interventions for achieving better BP control in Italy. REPS2/POB1 is an EH domain-containing protein, reported to be involved in signalling via RalBP1 and to play a role in endocytosis of EGF receptors. In our previous work we found quantitative changes in peripheral blood lymphocyte subpopulations (decrease in total T lymphocytes, increase in T suppressor cells and monocytes) in patients with idiopathic chronic glomerulonephritis (CGN).

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Blood examinations in industry: a comparison of blood cell counts from ear lobe and thumb pulp. Operative treatment consisted of arthrodesis of the pubic symphysis by bone grafting supplemented by a compression plate. Examination of the pathological changes in vitiligo after ultraviolet therapy revealed the presence of unusual cells. In addition, in AAV-shApoB-injected animals, genes involved in immune system activation or cell growth and death were affected, which was associated with increased hepatocyte proliferation. Genotyping was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.

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Postprandial changes in concentrations of all hormones showed a biphasic response with an initial rapid increase, later followed by a slower increase. Histological diagnosis was neuroendocrine tumor of the urinary bladder and he underwent two courses of trans-arterial infusion (neoadjuvant) chemotherapy. The effect of metoclopramide upon gastric motility and its value in barium progress meals. The shear magnitude of casualties required extensive infrastructure to support the surgeons at the battlefield and to care for the wounded. The purpose of this review is to describe the current nomenclature and diagnostic algorithms for epidermolysis bullosa, and methods for the management of cutaneous and mucosal lesions. No significantly increased risk was found for stillbirth, lethal congenital anomaly or neonatal deaths in relation to proximity to hazardous industrial facilities, except for deaths from congenital heart defects in 1983-93. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. Moreover, it seems likely that the Ciona hemocyanin-like sequences have enzymatic instead of respiratory functions. We describe an 8.5-year-old boy with facial dysmorphism consisting of a round and flat face, telecanthus, periorbital fullness, short nose, downturned corners of the mouth, and micrognathia. Caracurine V derivatives with different affinities to M2 were docked using GRID-fields.

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Satisfaction-based quality of life in CABG patients also remains on a lower level in comparison to patients without neurological complications. PSYCHIATRIC MANPOWER AND COMMUNITY MENTAL HEALTH: A SURVEY OF PSYCHIATRIC RESIDENTS. Vasomotor responses are time-dependent with a modest delay to peak vasodilation and tachyphylaxis with prolonged sustained infusion. For most patients with chronic kidney failure, kidney transplantation has the greatest potential for restoring a healthy and productive life. Diabetes was diagnosed according to the 1999 World Health Organization criteria based on a standard 75 g OGTT. Onset of chaotic dynamics in a ball mill: Attractors merging and crisis induced intermittency. Tumor size at the time of adoptive transfer determines whether tumor rejection occurs. After the operation, resected specimens were investigated macroscopically and microscopically to clarify the clinicopathological features and the risk factors of superficial cancer spread. 99Tcm-tetrofosmin, a lipophilic cationic radiotracer, and 99Tcm-sestamibi have also been reported to accumulate in thyroid tumours. However, thalidomide has been established to be useful in the treatment of various diseases including cancer.

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Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcepsilonRI. Sophisticated surgical treatments have been developed throughout the twentieth century and are largely successful. Participation in school sports clubs and related effects on cardiovascular risk factors in young males. Compensation of divergence is aimed for by rotation of the table and gantry angle modification, errors of compensation can already be checked optically from 0.5 degree. Detecting tau in serum of transgenic animal models after tau immunotherapy treatment. Osteolysis results from particle formation, and this has been most commonly reported to be secondary to polyethylene wear debris. Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). It is also hoped that the cost to formulate and use cidofovir topically will eventually decrease to a level that will allow more widespread use of this drug. A rare nidus for pulmonary thromboembolism after vertebroplasty.

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The release of nickel and other trace elements from electric kettles and coffee machines. The results suggested that embryonic/fetal pleural effusion in early pregnancy was associated with poor pregnancy outcome such as spontaneous abortion and chromosomal abnormality. A significant negative correlation was found between the MRI signal intensity in the synovium and the histologically determined iron content in macrophages located in the same region. Comparison of physiological responses to open water kayaking and kayak ergometry. The results indicate a higher level of micronuclei at all incubation times after exposure to the longer wave parts of UVR.

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Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. Correlation between fissured fibrous cap and contrast enhancement: preliminary results with the use of CTA and histologic validation. Some max dose of amiloride histological and ultrastructural aspects of skin components in homo- and autoplastic skin grafts in men with regard to the behavior of the connective tissue. We report the youngest case of postpneumonectomy gastric volvulus to date, occurring in an 18-year-old male with a history of inflammatory myofibroblastic pseudotumor who underwent left intrapericardial pneumonectomy, and presented 13 years later with chronic intermittent mesenteroaxial gastric volvulus. Our data represent the first report of a phenotype relevant to virulence for rpoE mutants. Although Or functional studies are in their initial stages in insects (mainly Drosophila), insects appear to be good models to establish fundamental concepts of olfaction with the development of powerful genetic, imaging, and behavioral tools. Mitotic anaphase cells of highly friable and embryogenic calluses which had been induced from immature embryos of two inbred lines of maize that have contrasting levels of heterochromatic knobs were analysed for the presence of abnormalities 3, 6, 9 and 12 months after the initiation of culture.

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The staining intensities of Ricinus communis agglutinin-I, Phaseolus vulgaris agglutinin-E and -L, Lens culinaris agglutinin and Erythrina cristagalli agglutinin (ECL) in the glomeruli of homozygous ICGN mice were stronger than those of heterozygous ICGN and ICR mice. The diagnosis results showed that the developed multi-period medical diagnosis method can help doctors make a proper diagnosis by the comprehensive information of multi-periods. The operating time is short, and there is a very high patient acceptance. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. The effect of PSM on risk of treatment failure, defined by either biochemical recurrence or necessity of any additional therapy (Cox regression), was evaluated. Identification of novel sequence-specific nuclear factors interacting with mouse senescence marker protein-30 gene promoter. The pregnant mice chronically treated with cocaine in the above-described manner represent one of the animal models producing offspring with widespread cortical dysplasias. The present review surveys the links between these three classes of molecular motors and the complex cellular processes of endocytosis and actin dynamics, and concentrates on a working model accounting for the function of cleocin and penicillin allergy class I myosins via recruitment of the machinery responsible for actin nucleation and elongation. In addition, the participants with the highest HRV showed the most differentiated emotion-modulated startle effects, whereas those with the lowest HRV, compared to those with the highest HRV, showed significantly potentiated startle to neutral foregrounds and marginally potentiated startle to pleasant foregrounds.

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Surgical management of epithelial ovarian cancer: a review of the literature. Problems in the treatment of old and recent traumatic lesions of the brain. The digestive system malignant tumor cleocin t gel reviews metastasis to the nose is rarer. The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. The Tn916 insertion in TX72 was mapped to the hasA locus (encoding hyaluronate synthase), which lies within the chromosomal region deleted in TX4. THE INFLUENCE OF RESERPINE ON THE MORTALITY AND BODY WEIGHT OF BIRD EMBRYOS. We started this study to know the sensitivity and specificity of this test as diagnostic tool of H.

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By using a nested PCR protocol, the sensitive detection of nine different polyomavirus genomes was demonstrated. Neurologists, gastroenterologists and general practitioners should be aware that coeliac disease can cause neurological diseases, especially polyneuropathy, cerebellar ataxia and encephalopathy. There was only one major postoperative complication (pneumatocele requiring repeat surgery). There are gender differences in IMT and wall stress, and the largest wall stress is found in the AA in men, which might be important in aneurysm development. Superhydrophobic antireflective silica films: fractal surfaces and laser-induced damage thresholds. This method is thus helpful for the determination of xenografts transplanted upon scid mice as well as in other experimental settings including adoptive transfer. Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Early hip fracture surgery with PFNA in patients who received antiplatelet and anticoagulant medications is safe and does not significantly increase perioperative blood loss, blood transfusion, and postoperative mortality and morbidity.

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Research on the variation of peak shape in capillary zone electrophoresis. Monoclonal antibodies against the extracellular portion of RTKs and small-molecule inhibitors of their tyrosine kinase activity are strategies in more advanced biaxin medicine phases of clinical development. Newer TNF blockers (etanercept, infliximab and adalimumab) have contributed greatly to the control of chronic inflammatory disease. The management of patients with advanced carcinoid tumors and islet cell carcinomas. Autologous fibrin sealant preparing system in coronary artery bypass grafting. On the basis of the IC50 values, the RT-CES system displays an equal sensitivity to the neutral red uptake assay at specific time points. One of these trials illustrates the danger of conducting effectiveness trials before the efficacy of an intervention is established. The clinical presentation closely mimicked primary thrombocytopenic purpura and led to the ineffective use of plasma exchange.

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Widespread Scaly Eruption in a Patient With Multiple Comorbidities. The Effects of Different Warm-up Volumes on the 100-m Swimming Performance: A Randomized Crossover Study. Based on this evidence, it is concluded that the sensitivity to acid stress in spinach could mask the potential role for oxalate to protect the plant roots from Al toxicity. Translational incorporation of S-nitrosohomocysteine into protein. Do clinical decision models improve the triage of acutely ill children?. A government mandate to start the partnership was inversely related to successful outcomes. Appraisal of the reliability and standardization of the procedure was performed utilizing startleometry. Patients with the Brugada sign and a family history of sudden death or a personal history of syncope are at a high risk of sudden death and therefore should be strongly considered for implantation of a defibrillator. Findings support the importance of PPD screenings among Mexican American fathers and suggest certain demographic, familial, and cultural factors may render men particularly vulnerable for maladjustment during the early infancy period.

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Nuclear pseudoinclusions in fine-needle aspiration cytology of hepatic angiomyolipoma: case report. This Mini-Review presents patient specific cutting blocks for the implantation of a total knee arthroplasty. Receiver operating characteristic (ROC) curves show that MSPD can detect more true peaks while keeping the false discovery rate lower than MassSpecWavelet and MALDIquant methods. Risk of sudden infant death syndrome and week of gestation of term birth. All the eight virulent and none of the two non-virulent strains tested exhibited apoptogenic activity.

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Blood and urine were analyzed at weeks 26, 52, 78, and 104 from 10 animals per sex per group. Males had significantly lower cholesterol, low density lipoprotein cholesterol levels than females for any given waist to hip ratio and conicity index, waist circumference and waist to height ratio. The paper shows the efficiency of combined use of magnetic laser therapy (MLT) and lymphotropic drug therapy in 40 teenagers with common forms of tuberculosis. Mean opening time of single-channel currents was little affected by the mutation. In addition, the resource has scaled up its representation of bacterial genomes, and now includes the genomes of over 9000 bacteria. Furthermore, susceptibility to ocular lesions after acquired toxoplasmosis is associated with high levels of interleukin-1 and tumor necrosis factor-alpha, whereas resistance is associated with high levels of interleukin-12 and interferon-gamma.

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Engineering stable cytoplasmic intrabodies with designed specificity. Surface plasmon resonance (SPR) analysis revealed different binding classes of mutant proteins. Effect of glucose on food intake in hypothalamic hyperphagic rats. The results of this work provide a system with which to study the positioning of chromatin regulatory proteins in either a repressed and/or active BXC at the cytological level. State-of-the-art lighting design is based on physically accurate lighting simulations of scenes such as offices. An intense lactate resonance was also present in the in vivo spectrum of primary melanoma.

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PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase. The cognate regulator element, however, has not yet been definitively identified. Electrokinetic experiments indicated a strong hydrodynamic shielding of the charge of the underlying PET layer by the hydrogel coatings and further proved that the swollen films were stable against shear stress and variation of pH. They also confirm the unlikelihood of nociceptive afferences involvement. The endotoxin values for strokes 1-5 were statistically significantly greater than the values from all other stroke intervals. However, there is a need for pharmacists to provide up-to-date drug information on fluoxetine to all healthcare professionals.

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