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Alfacal (Calcitriol)

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Alfacal is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones.

Other names for this medication:
Alfarich, Alphadol, Biocal, Bonestat, Bonetuf, Calcikind, Calcimet, Calcirol, Calcor, Caldikind, Caldix, Calotec, Denscal, Duracal, Kurecal, Laretol, Lctrol, Minroset, Netxod, Nutribone, Ostonex, Ostriol, Primacal, Rical, Riecal, Rockbon, Romical, Solbiocal, Sorvate, Vitalpha

Similar Products:
Lopid, Nolvadex, Feldene, Zudena, Tricor, Piroxivar, Lipidan, Valporate, Tetraicin, Pacinac, Venjoy, Rhythmiodarone, Ansemid, Zenegra, Excet,

Also known as: Calcitriol


Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. These results clarify the importance of purification of semiconductive materials for measurements of intrinsic mobility and optimal device performance. Neuroserpin expression in untreated prostate cancer was significantly higher than that in normal prostate. A standardised case history report was examined, and determinations of ionic calcium, vitamin D, osteocalcin, iPTH and urinary deoxypyridinoline, together with calcaneus densimetry measurements using a DEXA densimeter were also performed. Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. It is absolutely indicated in short and/or massively dilated ureter. Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee. Interventions aimed at improving patient perception of available resources might be useful to improve sexual functioning among patients with breast cancer. The patient initially showed mild improvement in symptoms after administration of an acetazolamide.

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In vivo antitumor activity and other pharmacological properties of halitoxin obtained from the sponge Haliclona viridis. Analysis included mixed-model regression adjusted for race/ethnicity, BMI, and socioeconomic status. Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines. This paper proposes another type of basic kernel, with which perfectly accurate primary and scatter absorbed dose calculations can be performed within a semi-infinite water phantom under certain irradiation conditions. Development and validation of analytical methods for monomeric and oligomeric migrants from nylon 12 packaging materials. Sequence analysis of Leuconostoc oenos DNA: organization of pLo13, a cryptic plasmid. PE exerted a similar spectrum of actions on layer V cortical neurons. Phenothiazine-induced reduction in 42-K efflux from isolated, electrically stimulated rat atria.

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Various inotropic effects of angiotensin II in post-ischaemic rat hearts depending on ischaemic time with possible involvement of protein kinase C. Advances in pathogenesis and current therapeutic strategies for cardiorenal syndrome. The probability of capture can be asymptotically approximated using this change in the Hamiltonian. We also assessed the correlation between the biomarkers and acute respiratory distress syndrome (ARDS), acute kidney injury (AKI) and acute heart failure. The omentum was pediculized on the left gastroepiploic artery and tightly sewn to the subcutaneous fatty tissue. Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.

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A PROPOSED MECHANISM FOR THE INDUCTION OF BENZOIC ACID OXIDASE IN MICROCOCCUS UREAE. Randomized controlled trials (RCTs) and quasi-RCTs comparing various primaquine dosing regimens with the standard primaquine regimen (15 mg/day for 14 days), or with no primaquine, in people with vivax malaria treated for blood stage infection with chloroquine. While results of intraoperative radiotherapy (IORT) during breast-conserving surgery (BCS) have been reported when used either as a boost at the time of surgery or as the sole radiation treatment, the clinical safety and cosmetic outcome of IORT in the Chinese Han population has not. UROPEPSIN EXCRETION DURING BALNEOTHERAPY WITH THE THERMAL SULFUR WATER OF BAD SCHALLERBACH. HIFU at 1.55 MHz was applied to the tumors with guidance from diagnostic US images. The IC50 of the dienone O-acetate (0.6 microM) was comparable to that of the clinically used anticancer drug cisplatin (0.7 microM).

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Shh reporter expression was restricted to the ventral (mesodermal) layer of the node in a pattern similar to endogenous Shh. The increasing organic/inorganic loads into the Bay stimulated the phytoplankton blooms which cause locally saturated DO concentrations in the eastern basin during autumn 1999. Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioning. Variations in the lipid profile of patients with chronic renal failure, treated with folic acid. Potassium channels are thought to be critical for lymphocyte activation, which suggests that hypertension may be an inflammatory disease initiated at the ion channel level. No evidence emerged for differential targeting of SAR sequences to a chromosome axis within native chromosomes.

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This study was designed to test the hypothesis that rapid bolus administration of an aqueous formulation of intravenous amiodarone causes less hypotension than a 10-minute infusion of the standard formulation, Cordarone IV. Identification of a novel transcription factor, GAGATA-binding protein, involved in androgen-mediated expression of prostate-specific antigen. These results indicate that the observed inhibition of PLD by lysophospholipids is due to their direct interaction rather than to an interaction between lysophospholipids and either Arf or PIP(2). Analysis of laminin structure and function with recombinant glycoprotein expressed in insect cells. Globe anesthesia (primary outcome), globe akinesia, lid akinesia, pupillary dilatation, and hypotony were scored separately on a 4-point scale during surgery by a masked surgeon. These data suggest that the SsDREB transcription factor is involved in the regulation of salt stress tolerance in tobacco by the activation of different downstream gene expression. In this paper, we present a simple method to smooth the boundaries of any Euler diagram drawing. Experience of high frequency electric welding in endocrine surgery. Primary NB cells showed CD40, CD80, CD86, OX40L, 4-1BBL, but not PD-1L and B7H2, mRNA expression.

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The aim of this study was to assess the presence of HPV-DNA in invasive breast carcinoma to determine the association between HPV infection and breast carcinoma. Influence of tumour necrosis factor-alpha on the expression of Fc IgG and IgA receptors, and other markers by cultured human blood monocytes and U937 cells. Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. The study of this reaction led to the discovery of an unprecedented substituent effect on the diastereoselectivity of the Mo(CO)6 mediated allenic Pauson-Khand reaction. Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease. Deletion at the C terminus of PKCalpha has no effect on 12-O-tetradecanoylphorbol-13-acetate-induced translocation.

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Latent myasthenia in a patient with a cystic dysembryoma of the mediastinum. Distribution of carboxylic esterases of some foregut derivatives zovirax 800 mg price in the rat. Establishment of a new methicillin resistant Staphylococcus aureus animal model of osteomyelitis. The operated who had had the internal drainage of the biliary ducts conduted preoperatively, suffered from more complications in total as well as from more infectious complications, compared with the patients without the drainage. Urogenital sinus mesenchymal (UGSM) cells derived from embryonic rodent show potent inductive effects for prostate regeneration. Extinction data were also similar to those obtained after training on multiple schedules of different reinforcement frequency.

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Functional monitoring of the ERG and PLR are useful objective techniques for the detection of retina and optic nerve deficits. Nickel was found at one position in the binuclear site and the other metal was indicated to be copper - a surprising result, implying a previously unrecognized role for copper. The CYP709B family of P450s includes three gene members, CYP709B1, CYP709B2 and CYP709B3, which have high amino acid sequence similarity and lack reports elucidating biological functions. It was also found that human pt-GalNAc-T was identical to the gene WBSCR17, which is reported to be in the critical region of patients with Williams-Beuren Syndrome, a neurodevelopmental disorder, and to ditropan xl mg be predominantly expressed in brain and heart. The Cancer Drugs Fund and Patient Acces Schemes within the UK: Increased Access to Oncology Medicines or Reduced Value For Money?. These data suggest that heavy physical activity may trigger SAH. To report the financial impact of using modern lens and vitreoretinal surgical techniques. Although it is not possible to establish preoperatively that the atrium is completely calcified and impossible to incise, when predisposing factors and evidence of complete transmural calcification are present, the surgeon should be aware of this possibility and should weigh carefully the decision to operate. Plaque removal efficacy of the V-shaped toothbrush with new designs in bristle arrangement. Preliminary observations on chromosomes of Telmatobius schreiteri.

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Inner inhibitory substances with high activity exists in Acanthopanax senticosus fruits and their outer coats, middle coats and the seeds. In order to find out whether this newly discovered sarcolemma-associated NOS/NO system represents a general signalling mechanism in the murine rodent heart and whether its properties are comparable to those in skeletal muscle fibres, immunohistochemical and catalytic histochemical methods (including image analysis) were applied to the heart and extensor digitorum longus (EDL) and tongue muscles of wild type and mutant mice. Reconstruction with microvascular free flaps by visiting microsurgeons. The proposed method allows rapid and reliable measurement of keto-acids. It also directly interacts with rabaptin5, an essential component of endosome fusion. The severity of dysautonomia in the rabbit ranges from isolated cardiovagal impairment to severe panautonomic failure with fixed mydriasis, gastroparesis, dry eyes, impaired heart rate variability, hypotension, and low plasma catecholamines. In contrast to the effects of electroconvulsive shock (ECS) on post-synaptic 5-HT(1A) receptor function in animals, which have chiefly been measured in the hippocampus using electrophysiological techniques, ECT in humans does not induce an increase in sensitivity of post-synaptic 5-HT(1A) receptors in the hypothalamus. Four oligodeoxynucleotide decamer primers showed species-specific amplification products between white spruce and Engelmann spruce.

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The effect of mifepristone administration on leukocyte populations, matrix metalloproteinases and inflammatory mediators in the first trimester cervix. The reference standard was obtained by consensus review using all six datasets. It could be tried can i take allegra while on antibiotics in other bacterial genera to obtain respective signature patterns and thereby PCR primers, for their rapid tracking in the environmental samples. A Liquid Junction Photoelectrochemical Solar Cell Based on p-Type MeNH3PbI3 Perovskite with 1.05 V Open-Circuit Photovoltage. ON THE SIGNIFICANCE OF LONGITUDINAL STUDIES ON THE MORBIDITY AND THE LIVING CONDITIONS OF THE RURAL POPULATION IN THE GERMAN FEDERAL REPUBLIC.

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Feedback via thalamic nuclei is critical in determining the forms of these quantities, the transition between sleep and waking, and stability against seizures. Cor triatriatum sinistrum--value of pulmonary vein flow in hemodynamic assessment. An investigation of the possible effects of prostaglandins E-1, F-2alpha and F-2beta on pregnancy in mice and rats. To prevent recurrence, anterior gastropexy was performed using percutaneous sutures through the abdominal wall and stomach with the gastroscope in place. The objectives of this study were to assess the perception of CFs by various categories of stakeholders, identify the possible uses of CFs, and determine whether one format should be preferred to another. Determination of 17-hydroxycorticoids in human peripheral blood. Ecological benchmarks, and their corresponding indicators, will be challenging to identify and use. The infant had an unimpaired development over a follow-up of 4 years. Rotavirus infection plays an important role in the severity of ADD among Colombian children.

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The tumor volumes before (V1, at day 13) and after treatment (V2, at day 28) were determined by MRI and the mean tumor growth ratio (V2/V1) was calculated. AGE inhibitors might present an emerging therapeutic approach with significant applications in the context of PCOS and infertility. Our data suggest that in contrast to the proposed feedback loop in the early embryonic growth plate, which requires the presence of the perichondrium, a feedback loop in the postnatal growth plate can be confined to the growth plate itself. We discuss the roles of PPARs in growth promotion in rodent hepatocarcinogenesis and potential therapeutic effects, including suppression of cancer growth and inflammation. The emerging invasive fungal pathogen Aspergillus fumigatus causes very serious infections among immunocompromised patient populations. These results raise cautions about the use of anesthetized animals to answer questions about the photic regulation of neuronal activity in the SCN. Laugier-Hunziker syndrome (LHS) is a rare acquired disorder characterized by macu-lar pigmentation of the lips and indapamide brand name usa oral mucosa, with frequent longitudinal melanonychia.

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These data show selective radiosensitization effects of ZM in A172 cells apparently due to increased radiation-induced apoptosis. Administration of 500 mg VitC for more than 10 weeks might decrease significantly TC and apo-B in hyperlipidemic patients. Connections between integrins and Rac GTPase pathways control gonad formation and function in C. Successful surgical repair for a patient with atrial septal defect and severe pulmonary hypertension--its surgical indication and prostaglandin E1 use for postoperative pulmonary hypertensive crisis. Our study shows that when simvastatin is administered at its MTD, only low micro-molar concentrations are achieved in plasma and PBMCs, which is consistent with the results observed in previous studies with lovastatin, but far lower than the concentrations required for anticancer effects in vitro. Recently, a new relapse has occurred which was again treated by extensive surgery. RABL6A Promotes Oxaliplatin Resistance in Tumor Cells and Is a New Marker of Survival for Resected Pancreatic Ductal Adenocarcinoma Patients.

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Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen. There is a paucity of information regarding the clinical experience of Asian hemodialysis patients. Upstream of JNKs, LPS induced a lasting activation of the constitutively present JNK kinase MKK4. Group C streptococci are common causative agents of epidemic infections in animals and a rare cause of meningitis in humans. Standardised incidence rates (SIRs) were calculated assuming a Poisson distribution. However, observational evidence indicates differences in outcome, which may relate to the preparations themselves or to the preservatives included.

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Juvenile hormone biosynthesis in larval and adult stick insects, Carausius morosus. Next, a Ybt biosynthetic editing enzyme was removed from the heterologous system which decreased native compound production but increased analog formation. The effects of carrageenans (CGNs) on the host defense mechanisms of macrophages against Salmonella infection were examined in vitro by using macrophage-like J774.1 cells. Analysis of rice ER-resident J-proteins reveals diversity and functional differentiation of the ER-resident Hsp70 system in plants. We recruited 45 CHR patients and 29 age- and gender-matched healthy controls (HC). Previous studies have identified the 185-203 amino acid sequence as a ligand for alpha(v)beta(3) integrin (Shahan, T. This acidification may contribute to feedback regulation of neuronal excitability. Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A). This diagnostic cohort study included 51 consecutive patients referred to a center for spinal surgery for clinical investigation of cervical and/or arm pain in Sweden during the period of November 2007 to February 2008.

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