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Actical (Calcitriol)
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Actical

Actical is the active form of vitamin D, normally made in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.

Other names for this medication:
Actical, Alphadol, Arachitol, Arcium, Biocal, Bonestat, Bonetuf, Calbec, Calbovic, Calcibest, Calcicare, Calcikind, Calcitriol, Calday, Caldikind, Caldix, Calsure, Caltive, Calvical, Calzem, Carcal, Cholical, Coecoral, Devita, Dmcal, Fovit, Ikmag, Koncal, Laretol, Minroset, Novadee, Ostriol, Primacal, Qpcal, Rical, Rockbon, Solbiocal, Sorvate, Statbone, Tobalt, Trolec, Vezocal, Vitalpha, Zaxial

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Rhinocort, Sporanox, Glucophage, Reminyl, Adipex, Sildigra, Risperdal, Duricef, Xenical, Colospa, Gluoformin, Utrovin, Allercet, Lasilix, Throtex, Ateroclar,

Also known as: Calcitriol

Description

Generic Actical is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Actical are intestine and bone. Generic Actical receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Actical may also act on the kidney and the parathyroid glands. Generic Actical is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Actical has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Actical, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Actical in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Actical produces other independent beneficial effects. Actical is also known as Calcitriol. Generic Actical treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Actical is Calcitriol. Brand name of Generic Actical is Actical.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Actical. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Actical and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Actical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. It is a frequently debated question whether technology drives biology or whether biology drives the development of new technologies. Statistics of measurements were entered into a multi-parametric mathematical model of the relative changes derived from the Geary-Hinkley transformation. Measuring the costs of primary care education in the ambulatory setting. tuberculosis from an unselected community-based study in northern Tanzania by IS6110 and polymorphic GC-rich repetitive-sequence (PGRS) methodologies. In these cells, higher IgG1 titers were observed in fed-batch cultures whilst product quality was conserved, demonstrating that miRNA-based cell line engineering provides an attractive approach toward the genetic optimization of CHO producer cells for industrial applications. After adjustment for socio-demographic characteristics and diagnosed psychiatric morbidity, higher MHW were significantly associated with increased self-reported prevalence and duration of NSPS, symptom-related healthcare utilization, GP-registered NSPS, alternative therapy consultations and lower sleep quality and quality of life. This is caused by an increased 1-alpha-hydroxylation reaction in activated macrophages. For both drug formulations and for each selection level, the cell lines were more resistant to free dox than to PIHCA-dox. The cell subpopulations eventually converge to an equilibrium distribution corresponding to the steady state of a chemostat, and halving of cellular content at cell division is the dominant driving force leading towards the population equilibrium state.

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Blood transfusion in acute and chronic pediatric settings: beliefs and practices. Ancestral reconstructions indicate reversals in Alchemilla from plants with a woody base to entirely herbaceous forms, a transition that is rarely reported in angiosperms. Prevalence and characteristics of dystrophin defects in adult male patients with dilated cardiomyopathy. Taeuiwon physicians also regularly prescribed Insamsokmium when the royal family performed the religious service or went into mourning. Regulation of RecA protein binding to DNA by opposing effects of ATP and ADP on inter-domain contacts: analysis by urea-induced unfolding of wild-type and C-terminal truncated RecA. This device has 445 N-type diodes in a 22 x 22 cm2 2-D array with variable spacing. Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed.

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Risk factors for progression and cancer-specific mortality (CSM) were determined using time-fixed and time-dependent Cox models. We observed a patient with keratosis pilaris, and her brother and an unrelated young man, whose findings led to a diagnosis of AMVC. The highly restricted early autoantibody responses and clinical features they show are not easily explained by mere loss of broad-specific self-tolerance inducing mechanisms, but hint at some more sharply focused early event(s) in autoimmunization. personality measurements of institutionalized delinquent girls and their temporal stability. Especially in a therapeutic role, PTCS has the advantage of maneuverability due to a shorter endoscopic length compared to other cholangioscopic modalities. This is a 136-residue, 10-stranded, antiparallel beta-barrel protein with seven beta-hairpins and is a member of the intracellular lipid binding protein (iLBP) family. Data from a population-based study of diet, cancer, and chronic disease were analyzed.

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The effect of a diagnostic dose of (99m)Tc-MDP on bone mineral density (BMD) estimations in the lumbar spine and the neck of femur was assessed in 20 patients using a Hologic QDR4500 scanner. We constructed multiple logistic regression models to assess the association between patient characteristics and having a CC, as well as between risk factors (diabetes, hyperlipidemia) for cardiovascular diseases (CVD) and CVD as one of the most prevalent CCs. Cloning, expression, and site-directed mutagenesis of inhibitor-2. Polyuronic substances (gums, mucilages, pectins, pseudocelluloses). Written by a volunteer patient advisor, this issue brief provides at 50-foot view of patient engagement as seen through the eyes of various stakeholders including payers, providers, and patients. Their reduced T-cell stimulatory capacity is less well studied and is a subject of the present study. Logistic regression was used to investigate the risk of each outcome in relation to proximity at birth to incinerators and crematoriums, adjusting for social class, year of birth, birth order, and multiple births. In the light of these results, PRP could be a viable alternative to accelerate the healing of fractures, late unions or non-unions. Then, acknowledging the limited resources and competing priorities facing American schools, practical science-based, best practices recommendations to promote IEQ and hence prevent or reduce potential occupant exposure to biological, chemical, and physical agents of concern were proposed. The anatomical and clinical significance of this interesting case is discussed.

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Eletriptan inhibited the trigeminal nerve mediated inflammation in the rat dura mater with equal potency and efficacy to sumatriptan. EEG-MEG Integration Enhances the Characterization of Functional and Effective Connectivity in the Resting State Network. During 2001, an estimated 107.5 million visits were made to hospital EDs, about 38.4 visits per 100 persons. Expression of joint moments in different reference systems affects the magnitude and ranking of athletes. To characterize the degree of similarity or difference in the method and analysis choices made by observational database research experts when presented with research study scenarios. The protocol used for restraint stress influenced the immunomodulatory effects of PT in intestinal and periodontal tissues.

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Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. Analysis of the factors associated with these deaths suggests that additional efforts are needed to ensure that caregivers do not leave infants unattended in the bathtub and to collect data that will further improve our understanding and management of these risks. Target-triggered cyclic assembly of DNA-protein hybrid nanowires for dual-amplified fluorescence anisotropy assay of small molecules. The autonomic nervous system plays an important role in the regulation of cardiac function and the regional distribution of cardiac nerve terminals can be visualized using scintigraphic techniques. Molecular basis of antibiotic resistance and beta-lactamase inhibition by mechanism-based inactivators: perspectives and future directions. All patients are still alive and free of disease between 34 and 56 months. A reversed-phase thin-layer chromatographic method was developed and applied to quantitate the lipophilicity of sparingly water-soluble eburnane alkaloids of therapeutic interest. Such chromosome specificity is unusual for plant paracentromeric repetitive DNA.

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The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. There is still no consensus concerning the precise value of the extent of surgery and the value of additional treatment modalities. Such a manifestation of increased vagal tone under spinal anaesthesia has not been reported previously. Other evidence suggests that these properties extend to other parts of the epithelium. singulair oral pill We performed a pilot randomized controlled trial comparing two modified ETTs designed specifically to prevent VAP, with the standard ETT, to test the feasibility of and inform planning for a large, pivotal, randomized trial.

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Multiple verruciform xanthomas in the setting of congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome. To directly study the regulation of cAMP response element (CRE)-mediated gene transcription by antidepressants, transgenic mice with a CRE-LacZ reporter gene construct were administered one of three different classes of antidepressants: a norepinephrine selective reuptake inhibitor (desipramine), a serotonin selective reuptake inhibitor (fluoxetine), or a monoamine oxidase inhibitor (tranylcypromine). As our approach to these complex problems evolves, we must keep a wary eye towards avoiding and minimizing the complications of the new techniques. Tyrosine nitration of mitochondrial proteins was observed under conditions of oxidative stress. TEM, XRD and XPS were employed to characterize the formation and chemical composition of AuNP-Thi-MoS2 nanocomposites. Mouse anti-ET-1 monoclonal antibody was used as the primary antibody. Finally, we show that single-step blade-coating and immersion in a ligand exchange solution such as the one containing methylammonium iodide can be used to fabricate well performing bottom-gate/bottom-contact PbS CQD field effect transistors with record subthreshold swing. These cases re-emphasize the dangers of trauma to the neuropathic limb in patients with diabetes. Do regional differences in adipocyte biology provide new pathophysiological insights?.

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CORRELATIONS BETWEEN HEMATIC FIBRONOGEN AND SEDIMENTATION VELOCITY IN ACUTE LEUKEMIAS. Scaffolds and biomaterials for tissue engineering: a review of clinical applications. Intestinal intraparietal hemorrhage due to administration of anticoagulants. Low-frequency Doppler ultrasonic cardiography in normal subjects and in patients with prior myocardial infarct. Violent lives of women: critical points for intervention--phase I focus groups. Pertinent data from the literature and our own work with Escherichia coli and Streptomyces are discussed. A genetic algorithm was then used to select the optimal set of sensors that best described the inhibitory activity of these alcohols within a linear regression model. In this study, we describe a large interstitial deletion of the Y short arm encompassing the AMELY locus in two unrelated individuals. The increase in dose enhancement percentage with graphite compared to perspex supporting assembly indicates that the electron backscatter is proportional to the atomic number of the medium.

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Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome. These results clearly suggest that the wrinkling and changes in dermal collagen content induced by Sq-OOH are qualitatively different to those induced by UVB exposure. There is a high level of dissatisfaction with tNSAID therapy of OA, arising in large part from a perception among many patients and physicians that these drugs are not always adequately effective in relieving the symptoms of this disease. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. By studying B lymphocytes derived from patients with Cornelia de Lange Syndrome, we observed a strong correlation between heterozygous loss-of-function mutations in the gene encoding the cohesin loading protein NIPBL and a shift toward the use of an alternative, microhomology-based end joining during CSR. This indicates that no change in the geometry of the Fe(III) site occurs over a wide range of pH. Ketamine administration diminishes operant responding but does not impair conditioned fear. A second and third challenge were performed at 4-week intervals. OMVs were found to be highly antigenic, as absorption of patient sera with OMVs greatly reduced reactivity with whole cells of P. A model of perceived risk for colorectal cancer among Japanese Americans.

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STAT5 controls essential cellular functions and is encoded by two genes, Stat5a and Stat5b. The processing of single-stranded DNA (ssDNA) formed periactin overdose on intermediate recombination structures is central to driving the specific outcomes of DSB repair during meiosis. Effects of prolonged endurance exercise on vascular endothelial and inflammation markers. riparius population dynamics should be more sensitive to effects on individual growth than C. Ethical issues in clinical research on fracture prevention in patients with osteoporosis. Insulin-like growth factors also have a modulatory role in neuronal function. The synthesis and antithrombotic activity of these inhibitors is reported. A modified Delphi method was then used to distill expert opinion into clinical statements that met a standardized definition of consensus. The use of the Mental Capacity Act Deprivation of Liberty Safeguards.

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