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Actalipid (Simvastatin)

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Actalipid is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease. Actalipid is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin


Actalipid is an HMG-CoA reductase inhibitor. Actalipid is used to: reduce the risk of heart attack, stroke, and death due to coronary heart disease; reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina; low high cholesterol and triglycerides; increase high-density lipoprotein (HDL, "good") cholesterol levels. Actalipid is also known as Imvastatin, Simlup, Simcardis, Ranzolont, Simvador. Actalipid works by reducing the production of certain fatty substances in the body, including cholesterol. Generic name of Actalipid is Simvastatin. Brand name of Actalipid is Actalipid.


Take Actalipid orally. Take Actalipid with or without food. Do not use grapefruit or grapefruit juice while taking Actalipid. Eating grapefruit or drinking grapefruit juice may increase the amount of Actalipid in blood, what may increase the serious side effects. If you want to achieve most effective results do not stop taking Actalipid suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actalipid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Actalipid if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Actalipid. These drugs should not be used while you are taking Actalipid:

cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Actalipid, tell your doctor if you are already using any of these other medicines:

lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Actalipid is safe for you, tell your doctor if you have:

history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Actalipid can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Actalipid if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Actalipid.

Actalipid pregnancy and breastfeeding warnings (more detail)

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Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit. The role of tumor necrosis factor-alpha in the aggravation of cerulein-induced pancreatitis in rats. It was the aim of this retrospective study to evaluate the frequency of recurrences and complications in patients treated by conventional surgical methods at our institution between 1980 and 1996 and to compare them to those observed in patients treated by minimal invasive methods reported in the literature. Significantly higher concentrations of the growth factors compared with normal do not appear to prevent or reverse structural remodelling in the airways. And analysis the requirement of performance evaluation, reference intervals and clinical evaluation study. Compared effects of hindlimb unloading versus terrestrial deafferentation on muscular properties of the rat soleus. Computational methods of analysis of protein-protein interactions. These associations were explained by higher volumes of CF, suggesting CF as a potential source of C3. A French multicenter study of over 700 patients with 22q11 deletions diagnosed using FISH or aCGH.

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Laparoscopic inguinal herniorrhaphy: initial experience in a community hospital. Role of the glutamate 332 residue in the transglycosylation activity of ThermusMaltogenic amylase. Laboratory evidences of disseminated intravascular coagulation (DIC) are also demonstrated in all degrees of severity in dengue patients. Among 874 CCLD patients identified in a nationwide survey, 428 patients were born between 1992 and 2012 and treated at 10 high-volume centers were retrospectively reviewed with statistical analysis. A retrospective review of 11 patients who underwent laparoscopic mesh rectopexy for refractory SRUS between 1993 and 1996. We show that the gap UPOs originate from saddle-node, period-doubling, and pitchfork bifurcations inside the periodic windows in the post-MC chaotic region of the bifurcation diagram. These results should aid in optimizing the application of HIFU for nonthermal tumor treatment.

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SPECT and 18F-FDG PET/CT imaging of multiple paragangliomas and a growth hormone-producing pituitary adenoma as phenotypes from a novel succinate dehydrogenase subunit D mutation. In general, animals enter the study when their health status is considered satisfactory on the basis of classical clinical investigations. In recent years, total arterial revascularization with use of the radial arteries has been promoted. Inhibition of lipopolysaccharide induced acute inflammation in lung by chlorination. Five hundred patients were recruited in a prospective, double-blind, placebo-controlled, randomized, multicenter phase II study. Faculty need to be proactive in seeking out relevant educational programs that include basic genetic/genomic concepts. In the current study we aimed at replicating our initial finding, exploring other TMS-based measures of excitability, and examining association with personality characteristics.

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Identification of perceptual limitations in mute autistic children. Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism. The purpose of this study was to assess the competencies and training needs for public health professionals managing chronic disease prevention programs. Diseases and medications associated with the occurrence of falls leading to medical treatment in elderly Finns (65 yrs or older) during a one-year period are presented. The aneurysm was clipped, and the patient emerged from anesthesia without neurological deficits. Socio-demographic and behavioural data were also included in the model. The effects of activin A and inhibin A were blocked by their binding protein, follistatin-288. Transition in the type of oscillation appears not only to depend on a change in cellular dynamics but also to be reflected in a different spatial distribution of the underlying neuronal networks. The genotyping results obtained with the Ovine SNP50K BeadChip in 2 fat tail breeds were compared with those obtained in 13 thin tail breeds. Impact of leachate composition on the advanced amaryl dosage oxidation treatment.

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Lithium-induced nephropathy: Rate of progression and prognostic factors. These results indicate that C57BL/6 and BALB/c mice have different susceptibilities to OVA-sensitization and OVA-induced pulmonary eosinophilia regulated by Th1- and Th2-type cytokines, independent of splenic Th1- and Th2-type cytokines production. The patient has been free of any recurrence during the follow-up period of one year. The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats. Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death. Careful treatment planning is therefore necessary in PTCL-NOS, given the possibility of spontaneous improvement of symptoms. The increased synthesis of beta-galactosidase and xylanase in P.

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Fate of organics during soil-aquifer treatment: sustainability of removals in the field. Activation of naive T cells by immature DC can induce tolerance. This occurs via signals through STAT1 and STAT3 to sn-glycero-3-phosphocholine. Retinal prosthesis technology can restore rudimentary form vision in patients with retinitis pigmentosa (RP) who have lost all eyesight. Plasmas (gas discharges) formed at the surface of liquids can promote a complex mixture of reactions in solution. A possible model of the mechanism of amoxil overdose rigidification and of the main residues involved is proposed. We studied 84 cirrhotic patients with normal systolic function to evaluate the prevalence of DDF using tissue Doppler imaging, and to investigate the possible correlation of DDF with outcomes (hospitalization, death) and with the specific causes of death. To optimize RT-PCR conditions, RNA was extracted from rat lungs after flushing, preservation, and reperfusion.

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